Reaction Details Report a problem with these data
Target
Glutaminyl-peptide cyclotransferase
Ligand
BDBM7949
Substrate
BDBM92450
Meas. Tech.
Inhibitor Assay
pH
8±0
Temperature
298.15±0 K
Ki
5748± 366 nM
Citation
 Huang, KF; Liaw, SS; Huang, WL; Chia, CY; Lo, YC; Chen, YL; Wang, AH Structures of human Golgi-resident glutaminyl cyclase and its complexes with inhibitors reveal a large loop movement upon inhibitor binding. J Biol Chem 286:12439-49 (2011) [PubMed]  Article 
Target
Name:
Glutaminyl-peptide cyclotransferase
Synonyms:
Glutaminyl Cyclase | Glutaminyl cyclase (QC) | Glutaminyl-peptide cyclotransferase | Glutaminyl-peptide cyclotransferase precursor (QC) | Glutaminyl-tRNA cyclotransferase | Glutamyl cyclase (QC) | QPCT | QPCT_HUMAN
Type:
Enzyme
Mol. Mass.:
40877.05
Organism:
Homo sapiens (Human)
Description:
Q16769
Residue:
361
Sequence:
MAGGRHRRVVGTLHLLLLVAALPWASRGVSPSASAWPEEKNYHQPAILNSSALRQIAEGTSISEMWQNDLQPLLIERYPGSPGSYAARQHIMQRIQRLQADWVLEIDTFLSQTPYGYRSFSNIISTLNPTAKRHLVLACHYDSKYFSHWNNRVFVGATDSAVPCAMMLELARALDKKLLSLKTVSDSKPDLSLQLIFFDGEEAFLHWSPQDSLYGSRHLAAKMASTPHPPGARGTSQLHGMDLLVLLDLIGAPNPTFPNFFPNSARWFERLQAIEHELHELGLLKDHSLEGRYFQNYSYGGVIQDDHIPFLRRGVPVLHLIPSPFPEVWHTMDDNEENLDESTIDNLNKILQVFVLEYLHL
  
Inhibitor
Name:
BDBM7949
Synonyms:
Imidazole C-4(5) deriv. 1 | N-[2-(1H-Imidazol-4-yl)ethyl]acetamide | N-omega-Acetylhistamine | N-w-acetylhistamine (AH)
Type:
Small organic molecule
Emp. Form.:
C7H11N3O
Mol. Mass.:
153.1817
SMILES:
CC(=O)NCCc1cnc[nH]1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM92450
Synonyms:
L-glutaminyl-2-naphthylamide
Type:
Substrate
Emp. Form.:
C15H17N3O2
Mol. Mass.:
271.3144
SMILES:
N[C@@H](CCC(N)=O)C(=O)Nc1ccc2ccccc2c1 |r|
Structure:
Search PDB for entries with ligand similarity: