Reaction Details
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Corticotropin-releasing factor-binding protein
Ligand
BDBM49070
Substrate
n/a
IC50
20000±n/a nM
Citation
PubChem, PC Dose Response confirmation of uHTS hits for small molecule antagonists of the CRF-binding protein and CRF-R2 receptor complex in 384 well format PubChem Bioassay (2012)[AID] More Info.:
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
Inhibitor
Name:
BDBM49070
Synonyms:
1-(1,3-benzodioxol-5-yl)-5-[(2-fluorobenzyl)thio]-1H-tetrazole | 1-(1,3-benzodioxol-5-yl)-5-[(2-fluorobenzyl)thio]tetrazole | 1-(1,3-benzodioxol-5-yl)-5-[(2-fluorophenyl)methylsulfanyl]-1,2,3,4-tetrazole | 1-(1,3-benzodioxol-5-yl)-5-[(2-fluorophenyl)methylsulfanyl]tetrazole | 1-(1,3-benzodioxol-5-yl)-5-[(2-fluorophenyl)methylthio]tetrazole | MLS000061962 | SMR000070823 | cid_573210
Type:
Small organic molecule
Emp. Form.:
C15H11FN4O2S
Mol. Mass.:
330.337
SMILES:
Fc1ccccc1CSc1nnnn1-c1ccc2OCOc2c1
Structure:
