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Target
Sentrin-specific protease 1
Ligand
BDBM94811
Substrate
n/a
IC50
4440±n/a nM
Citation
 PubChem, PC Dose response confirmation of small molecule inhibitors of the catalytic domain of the SUMO protease, SENP1 in a FRET assay PubChem Bioassay (2012)[AID] 
Target
Name:
Sentrin-specific protease 1
Synonyms:
SENP1 | SENP1_HUMAN | Sentrin-specific protease 1 (SENP1)
Type:
Protein
Mol. Mass.:
73500.42
Organism:
Homo sapiens (Human)
Description:
Q9P0U3
Residue:
644
Sequence:
MDDIADRMRMDAGEVTLVNHNSVFKTHLLPQTGFPEDQLSLSDQQILSSRQGHLDRSFTCSTRSAAYNPSYYSDNPSSDSFLGSGDLRTFGQSANGQWRNSTPSSSSSLQKSRNSRSLYLETRKTSSGLSNSFAGKSNHHCHVSAYEKSFPIKPVPSPSWSGSCRRSLLSPKKTQRRHVSTAEETVQEEEREIYRQLLQMVTGKQFTIAKPTTHFPLHLSRCLSSSKNTLKDSLFKNGNSCASQIIGSDTSSSGSASILTNQEQLSHSVYSLSSYTPDVAFGSKDSGTLHHPHHHHSVPHQPDNLAASNTQSEGSDSVILLKVKDSQTPTPSSTFFQAELWIKELTSVYDSRARERLRQIEEQKALALQLQNQRLQEREHSVHDSVELHLRVPLEKEIPVTVVQETQKKGHKLTDSEDEFPEITEEMEKEIKNVFRNGNQDEVLSEAFRLTITRKDIQTLNHLNWLNDEIINFYMNMLMERSKEKGLPSVHAFNTFFFTKLKTAGYQAVKRWTKKVDVFSVDILLVPIHLGVHWCLAVVDFRKKNITYYDSMGGINNEACRILLQYLKQESIDKKRKEFDTNGWQLFSKKSQEIPQQMNGSDCGMFACKYADCITKDRPINFTQQHMPYFRKRMVWEILHRKLL
  
Inhibitor
Name:
BDBM94811
Synonyms:
5-(3-chlorobenzyl)-3,5-dihydro-4H-pyridazino[4,5-b]indol-4-one | 5-(3-chlorobenzyl)-3H-pyridazin[4,5-b]indol-4-one | 5-[(3-chlorophenyl)methyl]-3H-pyridazino[4,5-b]indol-4-one | MLS000673153 | SMR000314394 | cid_16195479
Type:
Small organic molecule
Emp. Form.:
C17H12ClN3O
Mol. Mass.:
309.75
SMILES:
Clc1cccc(Cn2c3ccccc3c3cn[nH]c(=O)c23)c1
Structure:
Search PDB for entries with ligand similarity: