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Target
Sentrin-specific protease 1
Ligand
BDBM75839
Substrate
n/a
IC50
1180±n/a nM
Citation
 PubChem, PC Dose response confirmation of small molecule inhibitors of the catalytic domain of the SUMO protease, SENP1 in a FRET assay PubChem Bioassay (2012)[AID] 
Target
Name:
Sentrin-specific protease 1
Synonyms:
SENP1 | SENP1_HUMAN | Sentrin-specific protease 1 (SENP1)
Type:
Protein
Mol. Mass.:
73500.42
Organism:
Homo sapiens (Human)
Description:
Q9P0U3
Residue:
644
Sequence:
MDDIADRMRMDAGEVTLVNHNSVFKTHLLPQTGFPEDQLSLSDQQILSSRQGHLDRSFTCSTRSAAYNPSYYSDNPSSDSFLGSGDLRTFGQSANGQWRNSTPSSSSSLQKSRNSRSLYLETRKTSSGLSNSFAGKSNHHCHVSAYEKSFPIKPVPSPSWSGSCRRSLLSPKKTQRRHVSTAEETVQEEEREIYRQLLQMVTGKQFTIAKPTTHFPLHLSRCLSSSKNTLKDSLFKNGNSCASQIIGSDTSSSGSASILTNQEQLSHSVYSLSSYTPDVAFGSKDSGTLHHPHHHHSVPHQPDNLAASNTQSEGSDSVILLKVKDSQTPTPSSTFFQAELWIKELTSVYDSRARERLRQIEEQKALALQLQNQRLQEREHSVHDSVELHLRVPLEKEIPVTVVQETQKKGHKLTDSEDEFPEITEEMEKEIKNVFRNGNQDEVLSEAFRLTITRKDIQTLNHLNWLNDEIINFYMNMLMERSKEKGLPSVHAFNTFFFTKLKTAGYQAVKRWTKKVDVFSVDILLVPIHLGVHWCLAVVDFRKKNITYYDSMGGINNEACRILLQYLKQESIDKKRKEFDTNGWQLFSKKSQEIPQQMNGSDCGMFACKYADCITKDRPINFTQQHMPYFRKRMVWEILHRKLL
  
Inhibitor
Name:
BDBM75839
Synonyms:
(5Z)-2-anilino-5-(5-bromo-3-ethoxy-2-hydroxy-benzylidene)-2-thiazolin-4-one | (5Z)-2-anilino-5-[(5-bromo-3-ethoxy-2-hydroxyphenyl)methylidene]-1,3-thiazol-4-one | (5Z)-2-anilino-5-[(5-bromo-3-ethoxy-2-hydroxyphenyl)methylidene]-4-thiazolone | (5Z)-5-[(5-bromanyl-3-ethoxy-2-oxidanyl-phenyl)methylidene]-2-phenylazanyl-1,3-thiazol-4-one | 5-(5-Bromo-3-ethoxy-2-hydroxy-benzylidene)-2-phenylimino-thiazolidin-4-one | MLS001207354 | SMR000513259 | cid_1227683
Type:
Small organic molecule
Emp. Form.:
C18H15BrN2O3S
Mol. Mass.:
419.292
SMILES:
CCOc1cc(Br)cc(C=C2SC(Nc3ccccc3)=NC2=O)c1O |w:9.8,c:20|
Structure:
Search PDB for entries with ligand similarity: