Reaction Details
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Sentrin-specific protease 1
Ligand
BDBM94845
Substrate
n/a
IC50
4360±n/a nM
Citation
PubChem, PC Dose response confirmation of small molecule inhibitors of the catalytic domain of the SUMO protease, SENP1 in a FRET assay PubChem Bioassay (2012)[AID] More Info.:
Target
Name:
Sentrin-specific protease 1
Synonyms:
SENP1 | SENP1_HUMAN | Sentrin-specific protease 1 (SENP1)
Type:
Protein
Mol. Mass.:
73500.42
Organism:
Homo sapiens (Human)
Description:
Q9P0U3
Residue:
644
Sequence:
MDDIADRMRMDAGEVTLVNHNSVFKTHLLPQTGFPEDQLSLSDQQILSSRQGHLDRSFTCSTRSAAYNPSYYSDNPSSDSFLGSGDLRTFGQSANGQWRNSTPSSSSSLQKSRNSRSLYLETRKTSSGLSNSFAGKSNHHCHVSAYEKSFPIKPVPSPSWSGSCRRSLLSPKKTQRRHVSTAEETVQEEEREIYRQLLQMVTGKQFTIAKPTTHFPLHLSRCLSSSKNTLKDSLFKNGNSCASQIIGSDTSSSGSASILTNQEQLSHSVYSLSSYTPDVAFGSKDSGTLHHPHHHHSVPHQPDNLAASNTQSEGSDSVILLKVKDSQTPTPSSTFFQAELWIKELTSVYDSRARERLRQIEEQKALALQLQNQRLQEREHSVHDSVELHLRVPLEKEIPVTVVQETQKKGHKLTDSEDEFPEITEEMEKEIKNVFRNGNQDEVLSEAFRLTITRKDIQTLNHLNWLNDEIINFYMNMLMERSKEKGLPSVHAFNTFFFTKLKTAGYQAVKRWTKKVDVFSVDILLVPIHLGVHWCLAVVDFRKKNITYYDSMGGINNEACRILLQYLKQESIDKKRKEFDTNGWQLFSKKSQEIPQQMNGSDCGMFACKYADCITKDRPINFTQQHMPYFRKRMVWEILHRKLL
Inhibitor
Name:
BDBM94845
Synonyms:
(5R)-3-(3-chloranyl-2-oxidanyl-phenyl)-5-(3,4-dimethoxyphenyl)cyclohex-2-en-1-one | (5R)-3-(3-chloro-2-hydroxy-phenyl)-5-(3,4-dimethoxyphenyl)cyclohex-2-en-1-one | (5R)-3-(3-chloro-2-hydroxyphenyl)-5-(3,4-dimethoxyphenyl)-1-cyclohex-2-enone | (5R)-3-(3-chloro-2-hydroxyphenyl)-5-(3,4-dimethoxyphenyl)cyclohex-2-en-1-one | MLS002302564 | SMR001318592 | cid_44143780
Type:
Small organic molecule
Emp. Form.:
C20H19ClO4
Mol. Mass.:
358.815
SMILES:
COc1ccc(cc1OC)[C@H]1CC(=O)C=C(C1)c1cccc(Cl)c1O |c:15|
Structure:
