Reaction Details Report a problem with these data
Target
Prothrombin
Ligand
BDBM98167
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
186±0.0 nM
Citation
 Allerheiligen, S; Bauser, M; Schirok, H; Rester, U; Heitmeier, S; Gerdes, C; Von Degenfeld, G; Dittrich-Wengenroth, E; Saatmann, U; Straßburger, J; Straßburger, K; Münter, MJ; Lang, D Substituted oxazolidinones and their use US Patent  US8487111 Publication Date 7/16/2013 
Target
Name:
Prothrombin
Synonyms:
Activation peptide fragment 1 | Activation peptide fragment 2 | Coagulation factor II | F2 | Prothrombin precursor | THRB_HUMAN | Thrombin heavy chain | Thrombin light chain
Type:
Protein
Mol. Mass.:
70029.57
Organism:
Homo sapiens (Human)
Description:
P00734
Residue:
622
Sequence:
MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE
  
Inhibitor
Name:
BDBM98167
Synonyms:
US8487111, 6
Type:
Small organic molecule
Emp. Form.:
C23H22ClN3O5S
Mol. Mass.:
487.956
SMILES:
Cc1cc(ccc1-n1cccc(CCO)c1=O)N1C[C@H](CNC(=O)c2ccc(Cl)s2)OC1=O |r|
Structure:
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