Reaction Details
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Glutamine--fructose-6-phosphate aminotransferase [isomerizing]
Ligand
BDBM100280
Substrate
n/a
Ki
1.4e+3±n/a nM
Citation
Badet, B; Vermoote, P; Le Goffic, F Glucosamine synthetase from Escherichia coli: kinetic mechanism and inhibition by N3-fumaroyl-L-2,3-diaminopropionic derivatives. Biochemistry 27:2282-7 (1988) [PubMed] Article More Info.:
Target
Name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]
Synonyms:
GLMS_ECOLI | Glucosamine synthetase | glmS
Type:
PROTEIN
Mol. Mass.:
66883.46
Organism:
Escherichia coli (strain K12)
Description:
P17169
Residue:
609
Sequence:
MCGIVGAIAQRDVAEILLEGLRRLEYRGYDSAGLAVVDAEGHMTRLRRLGKVQMLAQAAEEHPLHGGTGIAHTRWATHGEPSEVNAHPHVSEHIVVVHNGIIENHEPLREELKARGYTFVSETDTEVIAHLVNWELKQGGTLREAVLRAIPQLRGAYGTVIMDSRHPDTLLAARSGSPLVIGLGMGENFIASDQLALLPVTRRFIFLEEGDIAEITRRSVNIFDKTGAEVKRQDIESNLQYDAGDKGIYRHYMQKEIYEQPNAIKNTLTGRISHGQVDLSELGPNADELLSKVEHIQILACGTSYNSGMVSRYWFESLAGIPCDVEIASEFRYRKSAVRRNSLMITLSQSGETADTLAGLRLSKELGYLGSLAICNVPGSSLVRESDLALMTNAGTEIGVASTKAFTTQLTVLLMLVAKLSRLKGLDASIEHDIVHGLQALPSRIEQMLSQDKRIEALAEDFSDKHHALFLGRGDQYPIALEGALKLKEISYIHAEAYAAGELKHGPLALIDADMPVIVVAPNNELLEKLKSNIEEVRARGGQLYVFADQDAGFVSSDNMHIIEMPHVEEVIAPIFYTVPLQLLAYHVALIKGTDVDQPRNLAKSVTVE
Inhibitor
Name:
BDBM100280
Synonyms:
(Z,5S)-5-amino-6-(carboxymethylamino)-1-diazonio-6-oxohex-1-en-2-olate | 6-Diazo-5-oxo-L-norleucylglycine
Type:
small organic molecule
Emp. Form.:
C8H12N4O4
Mol. Mass.:
228.2053
SMILES:
N[C@@H](CCC(=O)[CH-][N+]#N)C(=O)NCC(O)=O
Structure:
