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Target
Serine/threonine-protein kinase PAK 4
Ligand
BDBM101483
Substrate
n/a
Meas. Tech.
Enzymatic Assay
Ki
1.2e+2±n/a nM
EC50
>4000±0 nM
Citation
 Zhang, J; Guo, C; Bouzida, D; Dong, L; Li, H; Marakovits, JT; Yang, A; Hong, Y Pyrrolopyrazoles, potent kinase inhibitors US Patent  US8530652 Publication Date 9/10/2013 
Target
Name:
Serine/threonine-protein kinase PAK 4
Synonyms:
KIAA1142 | PAK4 | PAK4_HUMAN | p21-Activated kinase 4 (PAK4)
Type:
Protein
Mol. Mass.:
64098.01
Organism:
Homo sapiens (Human)
Description:
O96013
Residue:
591
Sequence:
MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACITSIQPGAPKTIVRGSKGAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPARARQENGMPEEPATTARGGPGKAGSRGRFAGHSEAGGGSGDRRRAGPEKRPKSSREGSGGPQESSRDKRPLSGPDVGTPQPAGLASGAKLAAGRPFNTYPRADTDHPSRGAQGEPHDVAPNGPSAGGLAIPQSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNRTR
  
Inhibitor
Name:
BDBM101483
Synonyms:
US8524710, 60 | US8530652, 10 | US8530652, 54
Type:
Small organic molecule
Emp. Form.:
C21H23ClN8O2
Mol. Mass.:
454.913
SMILES:
COc1nc(Cl)nc(Nc2[nH]nc3c2CN(C(=O)NC2CC2c2ccccc2)C3(C)C)n1
Structure:
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