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Target
Polyphenol oxidase 2
Ligand
BDBM106397
Substrate
n/a
Meas. Tech.
Spectrophotometric Assay
pH
6.8±n/a
Temperature
298.15±n/a K
IC50
274±n/a nM
Comments
extracted
Citation
 Liu, J; Chen, C; Wu, F; Zhao, L Microwave-assisted synthesis and tyrosinase inhibitory activity of chalcone derivatives. Chem Biol Drug Des 82:39-47 (2013) [PubMed]  Article 
Target
Name:
Polyphenol oxidase 2
Synonyms:
Monophenol monooxygenase | Monophenol oxidase | PPO2 | PPO2_AGABI | Tyrosinase
Type:
Protein
Mol. Mass.:
63923.66
Organism:
Agaricus bisporus (Common mushroom)
Description:
O42713
Residue:
556
Sequence:
MSLIATVGPTGGVKNRLNIVDFVKNEKFFTLYVRSLELLQAKEQHDYSSFFQLAGIHGLPFTEWAKERPSMNLYKAGYCTHGQVLFPTWHRTYLSVLEQILQGAAIEVAKKFTSNQTDWVQAAQDLRQPYWDWGFELMPPDEVIKNEEVNITNYDGKKISVKNPILRYHFHPIDPSFKPYGDFATWRTTVRNPDRNRREDIPGLIKKMRLEEGQIREKTYNMLKFNDAWERFSNHGISDDQHANSLESVHDDIHVMVGYGKIEGHMDHPFFAAFDPIFWLHHTNVDRLLSLWKAINPDVWVTSGRNRDGTMGIAPNAQINSETPLEPFYQSGDKVWTSASLADTARLGYSYPDFDKLVGGTKELIRDAIDDLIDERYGSKPSSGARNTAFDLLADFKGITKEHKEDLKMYDWTIHVAFKKFELKESFSLLFYFASDGGDYDQENCFVGSINAFRGTAPETCANCQDNENLIQEGFIHLNHYLARDLESFEPQDVHKFLKEKGLSYKLYSRGDKPLTSLSVKIEGRPLHLPPGEHRPKYDHTQARVVFDDVAVHVIN
  
Inhibitor
Name:
BDBM106397
Synonyms:
1-(-1-(4-methoxyphenyl)-3-phenylallylidene) thiosemicarbazide (18)
Type:
Small organic molecule
Emp. Form.:
C17H19N3OS
Mol. Mass.:
313.417
SMILES:
COc1ccc(cc1)C(CCc1ccccc1)=NN=CSN |w:17.19,19.21|
Structure:
Search PDB for entries with ligand similarity: