Reaction Details Report a problem with these data
Target
3-phosphoinositide-dependent protein kinase 1 [51-359]
Ligand
BDBM282331
Substrate
n/a
Meas. Tech.
PDK1 kinase assay
IC50
<100±n/a nM
Citation
 Arndt, J; Chan, T; Guckian, K; Kumaravel, G; Lee, W; Lin, EY; Scott, D; Sun, L; Thomas, J; van Vloten, K; Wang, D; Zhang, L; Erlanson, D Heterocyclic compounds useful as PDK1 inhibitors US Patent  US10030016 Publication Date 7/24/2018 
Target
Name:
3-phosphoinositide-dependent protein kinase 1 [51-359]
Synonyms:
3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) | 3-phosphoinositide-dependent protein kinase 1 | 3-phosphoinositide-dependent protein kinase 1 (aa 51-359) | PDK1 | PDK1 (aa 51-359) | PDPK1 | PDPK1_HUMAN | hPDK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
35302.26
Organism:
Homo sapiens (Human)
Description:
O15530[51-359]
Residue:
309
Sequence:
MDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPPKLT
  
Inhibitor
Name:
BDBM282331
Synonyms:
(S)-3-amino-6-(4-((5- cyano-3-(1-(4-fluorophenyl) ethylcarbamoyl)pyridin- 2-ylamino)methyl)phenyl)- N-(3-dimethylamino)propyl) pyrazine-2-carboxamide | US10030016, Example 211
Type:
Small organic molecule
Emp. Form.:
C32H34FN9O2
Mol. Mass.:
595.6699
SMILES:
C[C@H](NC(=O)c1cc(cnc1NCc1ccc(cc1)-c1cnc(N)c(n1)C(=O)NCCCN(C)C)C#N)c1ccc(F)cc1 |r|
Structure:
Search PDB for entries with ligand similarity: