Reaction Details Report a problem with these data
Target
Arachidonate 5-lipoxygenase-activating protein
Ligand
BDBM283677
Substrate
n/a
Meas. Tech.
Binding Assay
Ki
<0.1±n/a nM
Citation
Bacani, GM; Eccles, W; Fitzgerald, AE; Goldberg, SD; Hack, MD; Hawryluk, NA; Jones, WM; Keith, JM; Krawczuk, P; Lebsack, AD; Lee-Dutra, A; Liu, J; McClure, KJ; Meduna, SP; Pippel, DJ; Rosen, MD; Sales, ZS FLAP modulators US Patent US9884878 Publication Date 2/6/2018
More Info.:
Target
Name:
Arachidonate 5-lipoxygenase-activating protein
Synonyms:
5-lipoxygenase activating protein | 5-lipoxygenase-activating protein (FLAP) | 5-lipoxygenase/FLAP | AL5AP_HUMAN | ALOX5AP | FLAP | MK-886-binding protein
Type:
Enzyme
Mol. Mass.:
18159.90
Organism:
Homo sapiens (Human)
Description:
P20292
Residue:
161
Sequence:
MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNCVDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIILFLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPLLLIP
Inhibitor
Name:
BDBM283677
Synonyms:
5-[3-Fluoro-2'-(pyrimidin-2-yloxy)-4'- (trifluoromethyl)biphenyl-4-yl]pyrazin-2-amine | US9745328, Compound 551 | US9884878, Compound 551
Type:
Small organic molecule
Emp. Form.:
C21H13F4N5O
Mol. Mass.:
427.3544
SMILES:
Nc1cnc(cn1)-c1ccc(cc1F)-c1ccc(cc1Oc1ncccn1)C(F)(F)F