Reaction Details Report a problem with these data
Target
Glutaminyl-peptide cyclotransferase-like protein
Ligand
BDBM124972
Substrate
n/a
Meas. Tech.
Fluorometric Assay
pH
8±n/a
Ki
96±n/a nM
IC50
620±n/a nM
Comments
extracted
Citation
 Buchholz, M; Heiser, U; Hamann, A Inhibitors of glutaminyl cyclase US Patent  US8772508 Publication Date 7/8/2014 
Target
Name:
Glutaminyl-peptide cyclotransferase-like protein
Synonyms:
Glutaminyl Cyclase | Glutaminyl-peptide cyclotransferase-like protein (QC) | QPCTL | QPCTL_HUMAN
Type:
Protein
Mol. Mass.:
42941.16
Organism:
Homo sapiens (Human)
Description:
Q9NXS2
Residue:
382
Sequence:
MRSGGRGRPRLRLGERGLMEPLLPPKRRLLPRVRLLPLLLALAVGSAFYTIWSGWHRRTEELPLGRELRVPLIGSLPEARLRRVVGQLDPQRLWSTYLRPLLVVRTPGSPGNLQVRKFLEATLRSLTAGWHVELDPFTASTPLGPVDFGNVVATLDPRAARHLTLACHYDSKLFPPGSTPFVGATDSAVPCALLLELAQALDLELSRAKKQAAPVTLQLLFLDGEEALKEWGPKDSLYGSRHLAQLMESIPHSPGPTRIQAIELFMLLDLLGAPNPTFYSHFPRTVRWFHRLRSIEKRLHRLNLLQSHPQEVMYFQPGEPFGSVEDDHIPFLRRGVPVLHLISTPFPAVWHTPADTEVNLHPPTVHNLCRILAVFLAEYLGL
  
Inhibitor
Name:
BDBM124972
Synonyms:
US8772508, 3
Type:
Small organic molecule
Emp. Form.:
C18H25N5O5
Mol. Mass.:
391.4216
SMILES:
COc1cc(N\C(NCCCn2cncc2C)=C\[N+]([O-])=O)cc(OC)c1OC
Structure:
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