Reaction Details Report a problem with these data
Target
Opioid growth factor receptor-like protein 1
Ligand
BDBM15308
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
pH
7.4±n/a
Ki
4.1±n/a nM
Comments
extracted
Citation
 Fuchino, K; Goehring, RR; Shao, B; Taoda, Y; Tsuno, N; Whitehead, JW; Yao, J Substituted-quinoxaline-type piperidine compounds and the uses thereof US Patent  US8846929 Publication Date 9/30/2014 
Target
Name:
Opioid growth factor receptor-like protein 1
Synonyms:
OGFRL1 | OGRL1_HUMAN | Opioid Receptor-Like Receptor (ORL-1) | Opioid growth factor receptor-like protein 1 (ORL-1) | Opioid growth factor receptor-like protein 1 (ORL1) | Opioid receptor-like (ORL-1) | Opioid receptor-like (ORL1) | Opioid receptor-like protein 1 (OGL1) | Opioid receptor-like receptor (ORL1)
Type:
Protein
Mol. Mass.:
51247.53
Organism:
Homo sapiens (Human)
Description:
Q5TC84
Residue:
451
Sequence:
MGNLLGGVSFREPTTVEDCDSTWQTDSEPEPEEPGPGGGSEGPGQESEQPAQPPEQAGGRPGASPAPDEDAEAAGAEQGGDSTEATAKPKRSFYAARDLYKYRHQYPNFKDIRYQNDLSNLRFYKNKIPFKPDGVYIEEVLSKWKGDYEKLEHNHTYIQWLFPLREQGLNFYAKELTTYEIEEFKKTKEAIRRFLLAYKMMLEFFGIKLTDKTGNVARAVNWQERFQHLNESQHNYLRITRILKSLGELGYESFKSPLVKFILHEALVENTIPNIKQSALEYFVYTIRDRRERRKLLRFAQKHYTPSENFIWGPPRKEQSEGSKAQKMSSPLASSHNSQTSMHKKAKDSKNSSSAVHLNSKTAEDKKVAPKEPVEETDRPSPEPSNEAAKPRNTEKDSNAENMNSQPEKTVTTPTEKKESVSPENNEEGGNDNQDNENPGNTNCHDVVLVQ
  
Inhibitor
Name:
BDBM15308
Synonyms:
US8846929, 266
Type:
n/a
Emp. Form.:
C28H35N3O3
Mol. Mass.:
461.5958
SMILES:
[H][C@]12CC[C@]([H])(C[C@@]([H])(C1)n1c3ccccc3nc(C(O)=O)c1=O)N2C12CC3CC(C)(CC(C)(C3)C1)C2 |r,TLB:34:32:36:26.27.28,34:27:36:32.35.31,10:7:24:2.3,THB:31:32:26:29.36.28,31:29:26:32.35.34,33:32:26:29.36.28,33:32:36:26.27.28|
Structure:
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