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Target
D(3) dopamine receptor
Ligand
BDBM138432
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
Ki
6.5±n/a nM
Citation
 Rodriguez Sarmiento, RM; Wichmann, J Benzofurane compounds US Patent  US8877778 Publication Date 11/4/2014 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3 | DRD3_HUMAN | Dopamine D3 receptor | Dopamine D3 receptor (D3) | Dopamine D3 receptor (D3R) | Dopamine receptor | Dopamine receptor (D3) | Dopamine receptor D3
Type:
n/a
Mol. Mass.:
44243.43
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
400
Sequence:
MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
  
Inhibitor
Name:
BDBM138432
Synonyms:
US8877778, 36
Type:
Small organic molecule
Emp. Form.:
C25H35F3N2O3
Mol. Mass.:
468.5522
SMILES:
O[C@H](CC(=O)N[C@H]1CC[C@H](CCN2CCC(CC2)c2cccc3OCCc23)CC1)C(F)(F)F |r,wU:6.5,wD:9.9,1.0,(7.32,-2.15,;8.08,-.82,;7.32,.52,;5.77,.52,;5,-.82,;5,1.85,;3.47,1.85,;2.69,.52,;1.16,.52,;.39,1.85,;-1.16,1.85,;-1.92,.52,;-3.47,.52,;-4.24,-.82,;-5.77,-.82,;-6.54,.52,;-5.77,1.85,;-4.24,1.85,;-8.08,.52,;-8.85,1.85,;-10.4,1.85,;-11.16,.52,;-10.4,-.82,;-10.87,-2.28,;-9.62,-3.19,;-8.38,-2.28,;-8.85,-.82,;1.16,3.19,;2.69,3.19,;9.62,-.82,;11.16,-.82,;9.62,.72,;9.62,-2.36,)|
Structure:
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