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Target
Tyrosine-protein kinase receptor
Ligand
BDBM144301
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
0.34±n/a nM
Citation
 Shimada, I; Kurosawa, K; Matsuya, T; Iikubo, K; Kondoh, Y; Kamikawa, A; Tomiyama, H; Iwai, Y Diamino heterocyclic carboxamide compound US Patent  US8969336 Publication Date 3/3/2015 
Target
Name:
Tyrosine-protein kinase receptor
Synonyms:
EML4 ALK Fusion Protein
Type:
Protein
Mol. Mass.:
87656.33
Organism:
Homo sapiens (Human)
Description:
A9YLN7
Residue:
796
Sequence:
MDGFAGSLDDSISAASTSDVQDRLSALESRVQQQEDEITVLKAALADVLRRLAISEDHVASVKKSVSSKGQPSPRAVIPMSCITNGSGANRKPSHTSAVSIAGKETLSSAAKSGTEKKKEKPQGQREKKEESHSNDQSPQIRASPSPQPSSQPLQIHRQTPESKNATPTKSIKRPSPAEKSHNSWENSDDSRNKLSKIPSTPKLIPKVTKTADKHKDVIINQAKMSTREKNSQVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHYEDTILKSKNSMNQPGP
  
Inhibitor
Name:
BDBM144301
Synonyms:
US8969336, 406
Type:
Small organic molecule
Emp. Form.:
C26H36F3N7O2
Mol. Mass.:
535.6049
SMILES:
CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(C3)N(C)C)c(c2)C(F)(F)F)nc1N[C@H]1CC[C@H](O)CC1 |r,wU:31.33,wD:34.37,(3.9,1.43,;3.9,-.11,;2.57,-.88,;1.18,-.13,;-.15,-.9,;-.92,.43,;-.15,1.76,;-2.46,.43,;-.15,-2.44,;-1.48,-3.21,;-2.82,-2.44,;-2.82,-.9,;-4.15,-.13,;-5.48,-.9,;-6.82,-.13,;-8.28,-.61,;-9.19,.64,;-8.28,1.88,;-6.82,1.41,;-9.05,3.21,;-8.28,4.55,;-10.59,3.21,;-5.53,-2.47,;-4.15,-3.21,;-6.87,-3.24,;-8.2,-4.01,;-6.1,-4.58,;-7.64,-1.91,;1.18,-3.21,;2.52,-2.44,;3.85,-3.21,;5.19,-2.44,;5.19,-.9,;6.52,-.13,;7.85,-.9,;9.19,-.13,;7.85,-2.44,;6.52,-3.21,)|
Structure:
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