Reaction Details
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5-hydroxytryptamine receptor 5A
Ligand
BDBM148160
Substrate
n/a
Meas. Tech.
Binding Assay
pH
7.4±n/a
Temperature
310.15±n/a K
Ki
3.9±n/a nM
Comments
extracted
Citation
Hamaguchi, W; Kinoyama, I; Koganemaru, Y; Miyazaki, T; Kaneko, O; Sekioka, R; Washio, T Tetrahydroisoquinoline derivative US Patent US8962612 Publication Date 2/24/2015 More Info.:
Target
Name:
5-hydroxytryptamine receptor 5A
Synonyms:
5-HT-5 | 5-HT-5A | 5-hydroxytryptamine receptor 5 (5-HT5) | 5-hydroxytryptamine receptor 5A (5-HT5A) | 5HT5A_HUMAN | HTR5A | Serotonin (5-HT) receptor | Serotonin receptor 5A
Type:
Enzyme
Mol. Mass.:
40266.25
Organism:
Homo sapiens (Human)
Description:
P47898
Residue:
357
Sequence:
MDLPVNLTSFSLSTPSPLETNHSLGKDDLRPSSPLLSVFGVLILTLLGFLVAATFAWNLLVLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMEYTLRTRKCVSNVMIALTWALSAVISLAPLLFGWGETYSEGSEECQVSREPSYAVFSTVGAFYLPLCVVLFVYWKIYKAAKFRVGSRKTNSVSPISEAVEVKDSAKQPQMVFTVRHATVTFQPEGDTWREQKEQRAALMVGILIGVFVLCWIPFFLTELISPLCSCDIPAIWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAFKNFFSRQH
Inhibitor
Name:
BDBM148160
Synonyms:
US8962612, 60
Type:
Small organic molecule
Emp. Form.:
C17H17F2N5O
Mol. Mass.:
345.3466
SMILES:
[#6]-c1ccc(c2-[#6]-[#7](-[#6]-[#6]-c12)-[#6](=O)\[#7]=[#6](\[#7])-[#7])-c1ncc(F)cc1F
Structure:
