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Target
Mitogen-activated protein kinase kinase kinase 14
Ligand
BDBM158889
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
7.2±n/a
Ki
0.53±n/a nM
Comments
extracted
Citation
 Staben, S; Castanedo, G; Montalbetti, CA; Feng, J Tricyclic compounds and methods of use therefor US Patent  US9034866 Publication Date 5/19/2015 
Target
Name:
Mitogen-activated protein kinase kinase kinase 14
Synonyms:
HsNIK | M3K14_HUMAN | MAP3K14 | NF-kappa-beta-inducing kinase | NF-kappa-beta-inducing kinase (NF-kB) | NIK | Serine/threonine-protein kinase NIK
Type:
Protein
Mol. Mass.:
104059.50
Organism:
Homo sapiens (Human)
Description:
Q99558
Residue:
947
Sequence:
MAVMEMACPGAPGSAVGQQKELPKAKEKTPPLGKKQSSVYKLEAVEKSPVFCGKWEILNDVITKGTAKEGSEAGPAAISIIAQAECENSQEFSPTFSERIFIAGSKQYSQSESLDQIPNNVAHATEGKMARVCWKGKRRSKARKKRKKKSSKSLAHAGVALAKPLPRTPEQESCTIPVQEDESPLGAPYVRNTPQFTKPLKEPGLGQLCFKQLGEGLRPALPRSELHKLISPLQCLNHVWKLHHPQDGGPLPLPTHPFPYSRLPHPFPFHPLQPWKPHPLESFLGKLACVDSQKPLPDPHLSKLACVDSPKPLPGPHLEPSCLSRGAHEKFSVEEYLVHALQGSVSSGQAHSLTSLAKTWAARGSRSREPSPKTEDNEGVLLTEKLKPVDYEYREEVHWATHQLRLGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFRAEELMACAGLTSPRIVPLYGAVREGPWVNIFMELLEGGSLGQLVKEQGCLPEDRALYYLGQALEGLEYLHSRRILHGDVKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKSLLTGDYIPGTETHMAPEVVLGRSCDAKVDVWSSCCMMLHMLNGCHPWTQFFRGPLCLKIASEPPPVREIPPSCAPLTAQAIQEGLRKEPIHRVSAAELGGKVNRALQQVGGLKSPWRGEYKEPRHPPPNQANYHQTLHAQPRELSPRAPGPRPAEETTGRAPKLQPPLPPEPPEPNKSPPLTLSKEESGMWEPLPLSSLEPAPARNPSSPERKATVPEQELQQLEIELFLNSLSQPFSLEEQEQILSCLSIDSLSLSDDSEKNPSKASQSSRDTLSSGVHSWSSQAEARSSSWNMVLARGRPTDTPSYFNGVKVQIQSLNGEHLHIREFHRVKVGDIATGISSQIPAAAFSLVTKDGQPVRYDMEVPDSGIDLQCTLAPDGSFAWSWRVKHGQLENRP
  
Inhibitor
Name:
BDBM158889
Synonyms:
US9034866, 364
Type:
Small organic molecule
Emp. Form.:
C20H18FN3O2
Mol. Mass.:
351.3742
SMILES:
NC(=O)c1cn2C3CC(C3)c3cc(F)c(cc3-c2n1)C#CC1(O)CCC1 |(-3.88,4.09,;-4.97,3,;-6.46,3.4,;-4.58,1.51,;-5.59,.35,;-4.8,-.97,;-5.47,-2.36,;-4.8,-3.75,;-3.3,-4.09,;-3.85,-2.36,;-2.09,-3.13,;-.76,-3.9,;.57,-3.13,;1.91,-3.9,;.57,-1.59,;-.76,-.82,;-2.09,-1.59,;-3.3,-.63,;-3.16,.91,;1.91,-.82,;3.24,-.05,;4.58,.72,;3.24,1.49,;6.06,.32,;6.46,1.81,;4.97,2.21,)|
Structure:
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