Reaction Details
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Cholesteryl ester transfer protein
Ligand
BDBM184566
Substrate
n/a
Meas. Tech.
CETP In Vitro Assay
Temperature
310.15±n/a K
IC50
11±n/a nM
Comments
extracted
Citation
Trieselmann, T; Hamprecht, D; Wagner, H Furo[3,4-c]quinoline derivatives, medicaments containing such compounds, their use and process for their preparation US Patent US9150583 Publication Date 10/6/2015 More Info.:
Target
Name:
Cholesteryl ester transfer protein
Synonyms:
CETP | CETP_HUMAN | Cholesteryl ester transfer protein (CETP) | Lipid transfer protein I
Type:
Enzyme
Mol. Mass.:
54751.53
Organism:
Homo sapiens (Human)
Description:
P11597
Residue:
493
Sequence:
MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDITGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTTAWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWIKQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVITASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRLMLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSSVMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSESVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGFPEHLLVDFLQSLS
Inhibitor
Name:
BDBM184566
Synonyms:
US9150583, 3
Type:
Small organic molecule
Emp. Form.:
C28H32F3NO4
Mol. Mass.:
503.5532
SMILES:
COc1cc(ccc1C(F)(F)F)[C@H]1OC2(CCOCC2)c2c1c(nc1CC3(CC3)C[C@H](O)c21)C(C)C |r|
Structure:
