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Target
Histone deacetylase 1
Ligand
BDBM50020897
Substrate
n/a
Meas. Tech.
Enzyme Assay
IC50
65±n/a nM
Citation
 Nan, F; Chen, F; Zhang, Y; Li, J; Zhou, Y; Su, M; Ding, J; Meng, L; Xie, X; Wang, S Thiazole compounds, methods for preparation and use thereof US Patent  US9216962 Publication Date 12/22/2015 
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Human
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM50020897
Synonyms:
CHEMBL3287255 | US9216962, CFH367-C
Type:
Small organic molecule
Emp. Form.:
C15H18N4O3S2
Mol. Mass.:
366.458
SMILES:
ONC(=O)CCCCNC(=O)c1nc(sc1C1CC1)-c1nccs1
Structure:
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