Reaction Details Report a problem with these data
Target
Carbonic anhydrase 2
Ligand
BDBM50321258
Substrate
n/a
Meas. Tech.
CO2 Hydration Assay
pH
7.5±n/a
Temperature
298.15±n/a K
Ki
392±n/a nM
Comments
extracted
Citation
 Alp, C; Maresca, A; Alp, NA; Gültekin, MS; Ekinci, D; Scozzafava, A; Supuran, CT Secondary/tertiary benzenesulfonamides with inhibitory action against the cytosolic human carbonic anhydrase isoforms I and II. J Enzyme Inhib Med Chem 28:294-8 (2013) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM50321258
Synonyms:
5-oxo-1-tosyl-2,5-dihydro-1Hpyrrol-2-yl acetate | CA inhibitor, 17 | CHEMBL1164744
Type:
Small organic molecule
Emp. Form.:
C13H13NO5S
Mol. Mass.:
295.311
SMILES:
CC(=O)OC1C=CC(=O)N1S(=O)(=O)c1ccc(C)cc1 |c:5|
Structure:
Search PDB for entries with ligand similarity: