Reaction Details Report a problem with these data
Target
Nociceptin receptor
Ligand
BDBM239943
Substrate
n/a
Meas. Tech.
Binding Assay
pH
7.4±n/a
Ki
18±n/a nM
Comments
extracted
Citation
 Nolte, B; Schröder, W; Linz, K; Englberger, W; Schick, H; Graubaum, H; Braun, B; Ozegowski, S; Bálint, J; Sonnenschein, H Substituted 4-aminocyclohexane derivatives US Patent  US9403767 Publication Date 8/2/2016 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM239943
Synonyms:
US9403767, 130
Type:
Small organic molecule
Emp. Form.:
C25H36N2O
Mol. Mass.:
380.5661
SMILES:
CN(C)C1(CCC(CC1)(N(C)CCCCO)c1ccccc1)c1ccccc1 |(4.26,-2.88,;2.92,-2.11,;3.83,-.86,;1.59,-2.88,;.05,-2.83,;-.77,-4.13,;-.04,-5.49,;1.5,-5.55,;2.31,-4.24,;-1.38,-6.26,;-2.28,-7.51,;-2.71,-5.49,;-4.04,-6.26,;-5.38,-5.49,;-6.71,-6.26,;-8.04,-5.49,;-.15,-7.03,;1.13,-7.89,;1.02,-9.43,;-.36,-10.1,;-1.64,-9.24,;-1.53,-7.7,;1.7,-1.34,;.42,-.48,;.53,1.05,;1.91,1.73,;3.19,.87,;3.08,-.67,)|
Structure:
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