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Target
Mu-type opioid receptor
Ligand
BDBM239869
Substrate
n/a
Meas. Tech.
Binding Assay
Temperature
298.15±n/a K
Ki
8.05±n/a nM
Comments
extracted
Citation
 Nolte, B; Schröder, W; Linz, K; Englberger, W; Schick, H; Graubaum, H; Braun, B; Ozegowski, S; Bálint, J; Sonnenschein, H Substituted 4-aminocyclohexane derivatives US Patent  US9403767 Publication Date 8/2/2016 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM239869
Synonyms:
US9403767, 24 | US9403767, 27
Type:
Small organic molecule
Emp. Form.:
C30H34N2O
Mol. Mass.:
438.6038
SMILES:
CN(C)C1(CCC(CC1)(N(C)C(=O)\C=C\c1ccccc1)c1ccccc1)c1ccccc1 |(-5.43,5.61,;-6.77,4.84,;-7.39,6.24,;-6.77,3.3,;-7.58,1.99,;-6.86,.63,;-5.32,.58,;-4.5,1.88,;-5.23,3.24,;-5.32,-.96,;-4.69,-2.37,;-6.65,-1.73,;-7.99,-.96,;-6.65,-3.27,;-7.99,-4.04,;-7.99,-5.58,;-6.65,-6.35,;-6.65,-7.89,;-7.99,-8.66,;-9.32,-7.89,;-9.32,-6.35,;-4.04,-.29,;-2.66,.39,;-1.38,-.47,;-1.49,-2.01,;-2.87,-2.68,;-4.15,-1.82,;-8.04,4.16,;-9.43,3.48,;-10.7,4.34,;-10.6,5.88,;-9.21,6.55,;-7.94,5.69,)|
Structure:
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