Reaction Details Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM294001
Substrate
n/a
Meas. Tech.
In Vitro Assay GPR40 Calcium Flux Assay
Temperature
298.15±n/a K
EC50
8.00±n/a nM
Comments
extracted
Citation
 Meegalla, S; Player, MR; Huang, H; Winters, MP Substituted benzothiophenyl derivatives as GPR40 agonists for the treatment of type II diabetes US Patent  US10106553 Publication Date 10/23/2018 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Human
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM294001
Synonyms:
(2S)-3-(5-((4-(1-(1H-Tetrazol-5- yl)pent-3-yn-2- yl)phenoxy)methyl)benzo[b] thiophen-3-yl)-5-(2- methoxyethoxy)-2- methylpyridine | US10106553, Compound 33
Type:
Small organic molecule
Emp. Form.:
C30H29N5O3S
Mol. Mass.:
539.648
SMILES:
COCCOc1cnc(C)c(c1)-c1csc2ccc(COc3ccc(cc3)[C@H](Cc3nnn[nH]3)C#CC)cc12 |r|
Structure:
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