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Target
Phosphodiesterase
Ligand
BDBM408659
Substrate
n/a
Meas. Tech.
Fluorescence polarization assay
Ki
88.9±n/a nM
Citation
 Converso, A; Rodzinak, K Substituted quinolinones as PDE9 inhibitors US Patent  US10376504 Publication Date 8/13/2019 
Target
Name:
Phosphodiesterase
Synonyms:
PDE9A2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
61651.45
Organism:
Macaca mulatta (Rhesus macaque)
Description:
C4PBI8
Residue:
533
Sequence:
MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTSCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETVEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLLCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCGLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILTEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKHSEGDCA
  
Inhibitor
Name:
BDBM408659
Synonyms:
4-(diethylamino)-2- oxo-1,2- dihydroquinoline-3- carbonitrile | US10376504, Example 1-10
Type:
Small organic molecule
Emp. Form.:
C14H15N3O
Mol. Mass.:
241.2884
SMILES:
CCN(CC)c1c(C#N)c(=O)[nH]c2ccccc12
Structure:
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