Reaction Details Report a problem with these data
Target
Egl nine homolog 1 [181-417]
Ligand
BDBM413199
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
3.16±n/a nM
Citation
 Brown, JW; Davis, M; Ivetac, A; Jones, B; Kiryanov, AA; Kuehler, J; Lanier, M; Miura, J; Murphy, S; Wang, X 6-(5-hydroxy-1H-pyrazol-1-yl)nicotinamide inhibitors of PHD US Patent  US10407409 Publication Date 9/10/2019 
Target
Name:
Egl nine homolog 1 [181-417]
Synonyms:
C1orf12 | EGLN1 | EGLN1_HUMAN | Egl nine homolog 1 (aa 181-417)
Type:
Enzyme
Mol. Mass.:
26555.51
Organism:
Homo sapiens (Human)
Description:
aa 181-417
Residue:
237
Sequence:
PNGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQLVSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTGEKGVRVELNKP
  
Inhibitor
Name:
BDBM413199
Synonyms:
(R)-2-fluoro-4-(5-hydroxy-1-(5-(octahydropyrrolo[1,2-a]pyrazine-2-carbonyl)pyridin-2-yl)-1H-pyrazol-4-yl)-3-methylbenzonitrile | US10407409, Example 334
Type:
Small organic molecule
Emp. Form.:
C24H23FN6O2
Mol. Mass.:
446.4768
SMILES:
Cc1c(F)c(ccc1-c1cnn(c1O)-c1ccc(cn1)C(=O)N1CCN2CCC[C@@H]2C1)C#N |r|
Structure:
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