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Target
Bromodomain-containing protein 4 [1-477]
Ligand
BDBM425728
Substrate
n/a
IC50
<1000±n/a nM
Citation
 Zhang, J; Buell, J; Chan, K; Ibrahim, PN; Lin, J; Pham, P; Shi, S; Spevak, W; Wu, G; Wu, J Heterocyclic compounds and uses thereof US Patent  US10519177 Publication Date 12/31/2019 
Target
Name:
Bromodomain-containing protein 4 [1-477]
Synonyms:
BRD4 | BRD4_HUMAN | Bromodomain-containing protein 4 (BRD4 (aa 1-477) | Bromodomain-containing protein 4 (aa 1-477) | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
53061.90
Organism:
Homo sapiens (Human)
Description:
aa (1-477)
Residue:
477
Sequence:
MSAESGPGTRLRNLPVMGDGLETSQMSTTQAQAQPQPANAASTNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEETEIMIVQAKGRGRGRKETGTAKPGVSTVPNTTQASTPPQTQTPQPNPPPVQATPHPFPAVTPDLIVQTPVMTVVPPQPLQTPPPVPPQPQPPPAPAPQPVQSHPPIIAATPQPVKTKKGVKRKADTTTPTTIDPIHEPPSLPPEPKTTKLGQRRESSRPVKPPKKDVPDSQQHPAPEKSSKVSEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPEEPVVAVSSPAVPPPT
  
Inhibitor
Name:
BDBM425728
Synonyms:
US10519177, Compound P-0928 | [4-[6-(3,5-dimethylisoxazol-4-yl)- 1-(1-phenylethyl)pyrrolo[3,2- b]pyridin-3-yl]phenyl]phosphonic acid
Type:
Small organic molecule
Emp. Form.:
C26H24N3O4P
Mol. Mass.:
473.4602
SMILES:
CC(c1ccccc1)n1cc(-c2ccc(cc2)P(O)(O)=O)c2ncc(cc12)-c1c(C)noc1C
Structure:
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