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Target
Induced myeloid leukemia cell differentiation protein Mcl-1
Ligand
BDBM429022
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Anisotropy Competition Assay
Ki
<50.0±n/a nM
Citation
 Lee, T; Bian, Z; Belmar, J; Christov, PP; Pelz, NF; Shaw, S; Kim, K; Tarr, JC; Olejniczak, ET; Zhao, B; Fesik, SW Substituted indole Mcl-1 inhibitors US Patent  US10533010 Publication Date 1/14/2020 
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms:
BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT
Type:
Membrane; Single-pass membrane protein
Mol. Mass.:
37332.87
Organism:
Homo sapiens (Human)
Description:
Q07820
Residue:
350
Sequence:
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
  
Inhibitor
Name:
BDBM429022
Synonyms:
US10533010, Example I-118 | US11208415, Example I-118
Type:
Small organic molecule
Emp. Form.:
C29H32Cl2N4O2
Mol. Mass.:
539.496
SMILES:
Cc1nn(C)c(C)c1-c1c(Cl)ccc2c(CCCOc3cc(C)c(Cl)c(C)c3)c3C(=O)NCCCn3c12 |(-1.26,5.31,;-2.59,6.08,;-3.07,7.54,;-4.61,7.54,;-5.38,8.88,;-5.08,6.08,;-6.42,5.31,;-3.84,5.17,;-3.84,3.63,;-5.17,2.86,;-6.5,3.63,;-5.17,1.32,;-3.84,.55,;-2.5,1.32,;-1.04,.85,;-.64,-.64,;.85,-1.04,;1.25,-2.53,;2.73,-2.93,;3.13,-4.41,;4.62,-4.81,;5.02,-6.3,;6.5,-6.7,;3.93,-7.39,;4.33,-8.88,;2.44,-6.99,;1.35,-8.08,;2.04,-5.5,;-.13,2.09,;1.4,2.09,;2.17,.76,;2.42,3.25,;2.14,4.77,;.79,5.5,;-.63,4.89,;-1.04,3.34,;-2.5,2.86,)|
Structure:
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