Reaction Details Report a problem with these data
Target
Acetyl-CoA carboxylase
Ligand
BDBM429272
Substrate
n/a
Meas. Tech.
ACCase Enzymatic Assay
IC50
1946±n/a nM
Citation
 Slomczynska, U; Dimmic, MW; Haakenson, Jr., WP; Bennett, JL; Shortt, BJ; Taylor, CM; Williams, DJ; Slater, M Acetyl-CoA carboxylase modulators US Patent  US10548313 Publication Date 2/4/2020 
Target
Name:
Acetyl-CoA carboxylase
Synonyms:
6.4.1.2 | ACCase | Acetyl-CoA carboxylase
Type:
PROTEIN
Mol. Mass.:
12114.64
Organism:
Zea mays
Description:
ChEMBL_106638
Residue:
109
Sequence:
DSATKTAQALLDFNREGLPLFILANWRGFSGGQRDLFEGILQAGSTIVENLRTYNQPAFVYIPMAGELRGGAWVVVDSKINPDRIECYAERTAKGNVLEPQGLIEIKFR
  
Inhibitor
Name:
BDBM429272
Synonyms:
2-((6-(4-bromophenyl)-3- cyano-4- (trifluoromethyl)pyridin-2- yl)thio)-2-phenylacetic acid | US10548313, Formula Ia-x | US11375716, Formula Ia-x
Type:
Small organic molecule
Emp. Form.:
C21H12BrF3N2O2S
Mol. Mass.:
493.296
SMILES:
OC(=O)C(Sc1nc(cc(c1C#N)C(F)(F)F)-c1ccc(Br)cc1)c1ccccc1
Structure:
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