Reaction Details Report a problem with these data
Target
Prostacyclin receptor
Ligand
BDBM444830
Substrate
n/a
Meas. Tech.
Homogeneous Time-Resolved Fluorescence (HTRF) Assay for Direct cAMP Measurement
EC50
61.1±n/a nM
Citation
 Tran, T; Chen, W; Kramer, BA; Sadeque, AJ; Shifrina, A; Shin, Y; Vallar, P; Zou, N Modulators of the prostacyclin (PGI2) receptor useful for the treatment of disorders related thereto US Patent  US10668033 Publication Date 6/2/2020 
Target
Name:
Prostacyclin receptor
Synonyms:
PGI receptor | PI2R_HUMAN | PRIPR | PTGIR | Prostacyclin (IP) Receptor | Prostacyclin receptor | Prostaglandin I | Prostaglandin I2 | Prostaglandin I2 receptor | Prostanoid IP receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40968.22
Organism:
Homo sapiens (Human)
Description:
The membranes prepared from human platelet were used in binding assay.
Residue:
386
Sequence:
MADSCRNLTYVRGSVGPATSTLMFVAGVVGNGLALGILSARRPARPSAFAVLVTGLAATDLLGTSFLSPAVFVAYARNSSLLGLARGGPALCDAFAFAMTFFGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLRMRWAQPGGAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSLGPRPRTGEDEVDHLILLALMTVVMAVCSLPLTIRCFTQAVAPDSSSEMGDLLAFRFYAFNPILDPWVFILFRKAVFQRLKLWVCCLCLGPAHGDSQTPLSQLASGRRDPRAPSAPVGKEGSCVPLSAWGEGQVEPLPPTQQSSGSAVGTSSKAEASVACSLC
  
Inhibitor
Name:
BDBM444830
Synonyms:
2-(((1r,4r)-4-((3-(3- chlorophenyl)-3- phenylureido)methyl) cyclohexyl)methoxy)acetic acid | US10668033, Compound 6
Type:
Small organic molecule
Emp. Form.:
C23H27ClN2O4
Mol. Mass.:
430.924
SMILES:
OC(=O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2cccc(Cl)c2)CC1 |r,wU:9.9,wD:6.5,(9.34,-2.31,;8,-1.54,;8,,;6.67,-2.31,;5.33,-1.54,;4,-2.31,;2.67,-1.54,;2.67,,;1.33,.77,;;-1.33,.77,;-2.67,,;-4,.77,;-4,2.31,;-5.33,,;-5.33,-1.54,;-6.67,-2.31,;-6.67,-3.85,;-5.33,-4.62,;-4,-3.85,;-4,-2.31,;-6.67,.77,;-8,,;-9.34,.77,;-9.34,2.31,;-8,3.08,;-8,4.62,;-6.67,2.31,;,-1.54,;1.33,-2.31,)|
Structure:
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