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Target
Putative sugar transporter
Ligand
BDBM453270
Substrate
n/a
Meas. Tech.
Lactate Excretion Assays
IC50
55±n/a nM
Citation
 Olszewski, K; Poyurovsky, M; Barsotti, A; Kim, J; Liu, KG Treatment of infectious diseases with glucose uptake inhibitors US Patent  US10729691 Publication Date 8/4/2020 
Target
Name:
Putative sugar transporter
Synonyms:
Hexose transporter 1
Type:
PROTEIN
Mol. Mass.:
56427.07
Organism:
Plasmodium falciparum
Description:
ChEMBL_456666
Residue:
504
Sequence:
MTKSSKDICSENEGKKNGKSGFFSTSFKYVLSACIASFIFGYQVSVLNTIKNFIVVEFEWCKGEKDRLNCSNNTIQSSFLLASVFIGAVLGCGFSGYLVQFGRRLSLLIIYNFFFLVSILTSITHHFHTILFARLLSGFGIGLVTVSVPMYISEMTHKDKKGAYGVMHQLFITFGIFVAVMLGLAMGEGPKADSTEPLTSFAKLWWRLMFLFPSVISLIGILALVVFFKEETPYFLFEKGRIEESKNILKKIYETDNVDEPLNAIKEAVEQNESAKKNSLSLLSALKIPSYRYVIILGCLLSGLQQFTGINVLVSNSNELYKEFLDSHLITILSVVMTAVNFLMTFPAIYIVEKLGRKTLLLWGCVGVLVAYLPTAIANEINRNSNFVKILSIVATFVMIISFAVSYGPVLWIYLHEMFPSEIKDSAASLASLVNWVCAIIVVFPSDIIIKKSPSILFIVFSVMSILTFFFIFFFIKETKGGEIGTSPYITMEERQKHMTKSVV
  
Inhibitor
Name:
BDBM453270
Synonyms:
2-(3-(4-((4-(1H-pyrazol-4-yl)phenyl)amino)-6-acetyl-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl)phenoxy)-N-(pentan-3-yl)acetamide | US10729691, Example 55
Type:
Small organic molecule
Emp. Form.:
C30H33N7O3
Mol. Mass.:
539.6281
SMILES:
CCC(CC)NC(=O)COc1cccc(c1)-c1nc2CN(Cc2c(Nc2ccc(cc2)-c2cn[nH]c2)n1)C(C)=O
Structure:
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