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Target
Mu-type opioid receptor
Ligand
BDBM469350
Substrate
n/a
Meas. Tech.
Human Mu-Opioid Peptide (hMOP) Receptor Binding Assay
Ki
120±n/a nM
Citation
 Kuehnert, S; Koenigs, R; Kless, A; Wegert, A; Konetzki, I; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807988 Publication Date 10/20/2020 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM469350
Synonyms:
US10807988, Example SC_3001 | cis-5-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo-8-phenyl-1,3- diazaspiro[4.5]decan-3-yl]-pyrimidine-2-carbonitrile
Type:
Small organic molecule
Emp. Form.:
C26H32N6O
Mol. Mass.:
444.5719
SMILES:
CN(C)[C@]1(CC[C@]2(CN(C(=O)N2CC2CCC2)c2cnc(nc2)C#N)CC1)c1ccccc1 |r,wU:6.11,3.2,(6.58,22.67,;5.1,23.06,;4.7,24.55,;4.01,21.98,;3.24,20.64,;1.7,20.64,;.93,21.98,;.02,23.22,;-1.44,22.75,;-1.44,21.21,;-2.69,20.3,;.02,20.73,;.5,19.26,;-.53,18.12,;-2.07,18.12,;-2.07,16.58,;-.53,16.58,;-2.69,23.65,;-2.53,25.18,;-3.77,26.09,;-5.18,25.46,;-5.34,23.93,;-4.1,23.02,;-6.43,26.37,;-7.67,27.27,;1.7,23.31,;3.24,23.31,;5.1,20.89,;4.7,19.4,;5.79,18.31,;7.27,18.71,;7.67,20.2,;6.58,21.28,)|
Structure:
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