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Target
Nociceptin receptor
Ligand
BDBM469810
Substrate
n/a
Meas. Tech.
Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay
Ki
1.60±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Jakob, F; Kless, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W; Schiene, K; Wegert, A 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807989 Publication Date 10/20/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM469810
Synonyms:
CIS-2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo-8-phenyl-1,3- diazaspiro[4.5]decan-3-yl]-N-(3-fluoro-pyridin-4-yl)-acetamide | US10807989, Example SC_1038
Type:
Small organic molecule
Emp. Form.:
C28H36FN5O2
Mol. Mass.:
493.6161
SMILES:
CN(C)[C@]1(CC[C@]2(CN(CC(=O)Nc3ccncc3F)C(=O)N2CC2CCC2)CC1)c1ccccc1 |r,wU:6.23,3.2,(-4.5,-8.63,;-6.04,-8.63,;-6.44,-7.14,;-7.13,-9.72,;-7.52,-11.21,;-9.01,-11.61,;-10.1,-10.52,;-11.13,-9.37,;-12.54,-10,;-13.87,-9.23,;-15.21,-10,;-15.21,-11.54,;-16.54,-9.23,;-17.87,-10,;-17.87,-11.54,;-19.21,-12.31,;-20.54,-11.54,;-20.54,-10,;-19.21,-9.23,;-19.21,-7.69,;-12.38,-11.53,;-13.47,-12.62,;-10.87,-11.85,;-10.1,-13.18,;-10.87,-14.52,;-12.36,-14.92,;-11.96,-16.4,;-10.47,-16.01,;-9.7,-9.03,;-8.22,-8.63,;-5.79,-10.49,;-5.79,-12.03,;-4.46,-12.8,;-3.13,-12.03,;-3.13,-10.49,;-4.46,-9.72,)|
Structure:
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