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Target
Nociceptin receptor
Ligand
BDBM469822
Substrate
n/a
Meas. Tech.
Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay
Ki
0.800±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Jakob, F; Kless, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W; Schiene, K; Wegert, A 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807989 Publication Date 10/20/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM469822
Synonyms:
CIS-2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo-8-phenyl-1,3- diazaspiro[4.5]decan-3-yl]-N-(5-methylsulfonyl-pyridin-2-yl)-acetamide | US10807989, Example SC_1050
Type:
Small organic molecule
Emp. Form.:
C29H39N5O4S
Mol. Mass.:
553.716
SMILES:
CN(C)[C@]1(CC[C@]2(CN(CC(=O)Nc3ccc(cn3)S(C)(=O)=O)C(=O)N2CC2CCC2)CC1)c1ccccc1 |r,wU:6.26,3.2,(-2.76,30.22,;-4.25,30.62,;-4.65,32.11,;-5.34,29.53,;-6.11,28.2,;-7.65,28.2,;-8.42,29.53,;-9.32,30.78,;-10.79,30.3,;-11.88,31.39,;-13.36,30.99,;-13.76,29.5,;-14.45,32.08,;-15.94,31.68,;-16.34,30.2,;-17.83,29.8,;-18.92,30.89,;-18.52,32.37,;-17.03,32.77,;-20.4,30.49,;-20,29,;-21.89,30.09,;-20.8,31.97,;-10.79,28.76,;-12.12,27.99,;-9.32,28.29,;-8.92,26.8,;-10.01,25.71,;-11.55,25.71,;-11.55,24.17,;-10.01,24.17,;-7.65,30.87,;-6.11,30.87,;-4.25,28.44,;-4.65,26.96,;-3.56,25.87,;-2.07,26.27,;-1.67,27.75,;-2.76,28.84,)|
Structure:
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