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Target
Nociceptin receptor
Ligand
BDBM469872
Substrate
n/a
Meas. Tech.
Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay
Ki
1.000±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Jakob, F; Kless, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W; Schiene, K; Wegert, A 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807989 Publication Date 10/20/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM469872
Synonyms:
CIS-2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo-8-phenyl-1,3- diazaspiro[4.5]decan-3-yl]-N-[(6-methyl-pyridin-2-yl)-methyl]-acetamide | US10807989, Example SC_1100
Type:
Small organic molecule
Emp. Form.:
C30H41N5O2
Mol. Mass.:
503.6788
SMILES:
CN(C)[C@]1(CC[C@]2(CN(CC(=O)NCc3cccc(C)n3)C(=O)N2CC2CCC2)CC1)c1ccccc1 |r,wU:6.24,3.2,(15.44,16.16,;16.53,15.08,;18.02,15.47,;16.13,13.59,;16.13,12.05,;14.8,11.28,;13.46,12.05,;12.17,12.89,;10.98,11.92,;9.49,12.32,;8.4,11.23,;8.8,9.74,;6.91,11.63,;5.82,10.54,;4.34,10.93,;3.94,12.42,;2.45,12.82,;1.36,11.73,;1.76,10.24,;.67,9.16,;3.25,9.85,;11.53,10.48,;10.76,9.15,;13.07,10.56,;14.16,9.47,;13.76,7.98,;12.42,7.21,;13.19,5.88,;14.53,6.65,;13.46,13.59,;14.8,14.36,;17.62,13.19,;18.02,11.7,;19.51,11.3,;20.59,12.39,;20.2,13.88,;18.71,14.28,)|
Structure:
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