Reaction Details Report a problem with these data
Target
Nociceptin receptor
Ligand
BDBM469882
Substrate
n/a
Meas. Tech.
Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay
Ki
1.60±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Jakob, F; Kless, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W; Schiene, K; Wegert, A 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807989 Publication Date 10/20/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM469882
Synonyms:
CIS-2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo-8-phenyl-1,3- diazaspiro[4.5]decan-3-yl]-N-(5-hydroxy-pyridin-2-yl)-acetamide | US10807989, Example SC_1111
Type:
Small organic molecule
Emp. Form.:
C28H37N5O3
Mol. Mass.:
491.6251
SMILES:
CN(C)[C@]1(CC[C@]2(CN(CC(=O)Nc3ccc(O)cn3)C(=O)N2CC2CCC2)CC1)c1ccccc1 |r,wU:6.23,3.2,(16.82,18.22,;17.59,16.89,;19.13,16.89,;16.82,15.55,;16.05,14.22,;14.51,14.22,;13.74,15.55,;12.83,16.8,;11.37,16.32,;10.03,17.09,;8.7,16.32,;8.7,14.78,;7.37,17.09,;6.03,16.32,;6.03,14.78,;4.7,14.01,;3.37,14.78,;2.03,14.01,;3.37,16.32,;4.7,17.09,;11.37,14.78,;10.03,14.01,;12.83,14.31,;13.23,12.82,;12.14,11.73,;10.6,11.73,;10.6,10.19,;12.14,10.19,;14.51,16.89,;16.05,16.89,;17.59,14.22,;16.82,12.88,;17.59,11.55,;19.13,11.55,;19.9,12.88,;19.13,14.22,)|
Structure:
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