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Target
Nociceptin receptor
Ligand
BDBM469908
Substrate
n/a
Meas. Tech.
Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay
Ki
0.900±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Jakob, F; Kless, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W; Schiene, K; Wegert, A 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807989 Publication Date 10/20/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM469908
Synonyms:
CIS-2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo-8-phenyl-1,3- diazaspiro[4.5]decan-3-yl]-N-(6-methylsulfonyl-pyridin-2-yl)-acetamide | US10807989, Example SC_1138
Type:
Small organic molecule
Emp. Form.:
C29H39N5O4S
Mol. Mass.:
553.716
SMILES:
CN(C)[C@]1(CC[C@]2(CN(CC(=O)Nc3cccc(n3)S(C)(=O)=O)C(=O)N2CC2CCC2)CC1)c1ccccc1 |r,wU:3.2,6.26,(16.98,31.77,;17.75,30.44,;19.29,30.44,;16.98,29.1,;16.21,27.77,;14.67,27.77,;13.9,29.1,;13,30.35,;11.53,29.87,;10.2,30.64,;8.87,29.87,;8.87,28.33,;7.53,30.64,;6.2,29.87,;6.2,28.33,;4.87,27.56,;3.53,28.33,;3.53,29.87,;4.87,30.64,;2.2,30.64,;.87,29.87,;1.11,31.73,;3.29,31.73,;11.53,28.33,;10.2,27.56,;13,27.86,;13.4,26.37,;12.31,25.28,;10.77,25.28,;10.77,23.74,;12.31,23.74,;14.67,30.44,;16.21,30.44,;17.75,27.77,;16.98,26.44,;17.75,25.1,;19.29,25.1,;20.06,26.44,;19.29,27.77,)|
Structure:
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