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Target
Mu-type opioid receptor
Ligand
BDBM472053
Substrate
n/a
Meas. Tech.
Receptor Binding Assay
Ki
1.50±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Kless, A; Wegert, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W; Schiene, K; Konetzki, I 3-((hetero-)aryl)-alkyl-8-amino-2-oxo-l,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10829480 Publication Date 11/10/2020 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM472053
Synonyms:
CIS-1-(Cyclobutyl-methyl)-8-dimethylamino-8-phenyl-3-(pyridin-4-yl-methyl)-1,3- diazaspiro[4.5]decan-2-one | US10829480, Example SC_2103
Type:
Small organic molecule
Emp. Form.:
C27H36N4O
Mol. Mass.:
432.6009
SMILES:
CN(C)[C@]1(CC[C@]2(CN(Cc3ccncc3)C(=O)N2CC2CCC2)CC1)c1ccccc1 |r,wU:6.19,3.2,(-8.3,30.42,;-7.53,29.08,;-5.99,29.08,;-8.3,27.75,;-9.07,26.42,;-10.61,26.42,;-11.38,27.75,;-12.29,28.99,;-13.75,28.52,;-15.09,29.29,;-16.57,28.89,;-17.66,29.98,;-19.15,29.58,;-19.55,28.09,;-18.46,27,;-16.97,27.4,;-13.75,26.98,;-15.09,26.21,;-12.29,26.5,;-11.89,25.02,;-12.98,23.93,;-14.52,23.93,;-14.52,22.39,;-12.98,22.39,;-10.61,29.08,;-9.07,29.08,;-7.53,26.42,;-8.3,25.08,;-7.53,23.75,;-5.99,23.75,;-5.22,25.08,;-5.99,26.42,)|
Structure:
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