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Target
Polyphenol oxidase 1
Ligand
BDBM473779
Substrate
n/a
Meas. Tech.
Tyrosinase Inhibition Assay
IC50
72000±n/a nM
Citation
 Jia, Q; Zhao, J Diarylalkanes as potent inhibitors of binuclear enzymes US Patent  US10857082 Publication Date 12/8/2020 
Target
Name:
Polyphenol oxidase 1
Synonyms:
PPO1 | PPO1_AGABI | Polyphenol oxidase | Tyrosinase
Type:
Enzyme
Mol. Mass.:
63902.83
Organism:
Agaricus bisporus (White button mushroom)
Description:
Q00024
Residue:
568
Sequence:
MSHLLVSPLGGGVQPRLEINNFVKNDRQFSLYVQALDRMYATPQNETASYFQVAGVHGYPLIPFDDAVGPTEFSPFDQWTGYCTHGSTLFPTWHRPYVLILEQILSGHAQQIADTYTVNKSEWKKAATEFRHPYWDWASNSVPPPEVISLPKVTITTPNGQKTSVANPLMRYTFNSVNDGGFYGPYNQWDTTLRQPDSTGVNAKDNVNRLKSVLKNAQASLTRATYDMFNRVTTWPHFSSHTPASGGSTSNSIEAIHDNIHVLVGGNGHMSDPSVAPFDPIFFLHHANVDRLIALWSAIRYDVWTSPGDAQFGTYTLRYKQSVDESTDLAPWWKTQNEYWKSNELRSTESLGYTYPEFVGLDMYNKDAVNKTISRKVAQLYGPQRGGQRSLVEDLSNSHARRSQRPAKRSRLGQLLKGLFSDWSAQIKFNRHEVGQSFSVCLFLGNVPEDPREWLVSPNLVGARHAFVRSVKTDHVAEEIGFIPINQWIAEHTGLPSFAVDLVKPLLAQGLQWRVLLADGTPAELDSLEVTILEVPSELTDDEPNPRSRPPRYHKDITHGKRGGCREA
  
Inhibitor
Name:
BDBM473779
Synonyms:
1-(2-hydroxy-4-methoxyphenyl)-3-(2',3',4',5'-tetrahydro-benzo(b)dioxoin-8'-yl)-1-propanol | US10857082, Table 2.13
Type:
Small organic molecule
Emp. Form.:
C18H24O5
Mol. Mass.:
320.3802
SMILES:
COc1ccc(O)c(c1)C(O)CCC1=CCCC2OCCOC12 |t:14|
Structure:
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