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Target
Apelin receptor
Ligand
BDBM481025
Substrate
n/a
Meas. Tech.
[35S]GTPγS Binding Assay
EC50
28.0±n/a nM
Citation
 Chen, N; Chen, Y; Debenedetto, MV; Dransfield, PJ; Harvey, JS; Heath, JA; Houze, J; Khakoo, AY; Lai, S; Ma, Z; Nishimura, N; Pattaropong, V; Swaminath, G; Yeh, W; Kreiman, C Triazole phenyl compounds as agonists of the APJ receptor US Patent  US10906890 Publication Date 2/2/2021 
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
  
Inhibitor
Name:
BDBM481025
Synonyms:
US10906890, Example 34.0
Type:
Small organic molecule
Emp. Form.:
C26H33N5O6S
Mol. Mass.:
543.635
SMILES:
COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H]2CCCN(C2)C(=O)OC(C)(C)C)nnc1-c1ccccc1 |r,wD:16.16,(-5.87,-4.46,;-4.54,-5.23,;-3.2,-4.46,;-3.2,-2.92,;-1.87,-2.15,;-.54,-2.92,;-.54,-4.46,;.8,-5.23,;2.13,-4.46,;-1.87,-5.23,;-1.87,-6.77,;-.62,-7.67,;.86,-7.27,;1.95,-8.36,;.86,-9.45,;3.04,-9.45,;3.04,-7.27,;2.64,-5.79,;3.73,-4.7,;5.22,-5.1,;5.62,-6.58,;4.53,-7.67,;7.11,-6.98,;7.5,-8.47,;8.19,-5.89,;7.8,-4.41,;8.88,-3.32,;6.31,-4.01,;7.4,-2.92,;-1.1,-9.14,;-2.64,-9.14,;-3.12,-7.67,;-4.6,-7.27,;-5.69,-8.36,;-7.18,-7.96,;-7.58,-6.48,;-6.49,-5.39,;-5,-5.79,)|
Structure:
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