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Target
TGF-beta receptor type-1
Ligand
BDBM481202
Substrate
n/a
Meas. Tech.
Kinase Activity Assay
IC50
28.0±n/a nM
Citation
 Yu, S; Yang, F; Yan, J; Wu, X; He, F; Tao, W Five-membered heteroaryl ring bridged ring derivative, preparation method therefor and medical use thereof US Patent  US10906905 Publication Date 2/2/2021 
Target
Name:
TGF-beta receptor type-1
Synonyms:
ALK-5 | ALK5 | Activin A receptor type II-like protein kinase of 53kD | Activin receptor-like kinase 5 | SKR4 | Serine/threonine-protein kinase receptor R4 | TGF-beta receptor type I | TGF-beta type I receptor | TGFBR1 | TGFR-1 | TGFR1_HUMAN | TbetaR-I | Transforming growth factor-beta receptor type I
Type:
enzyme
Mol. Mass.:
55968.24
Organism:
Homo sapiens (Human)
Description:
P36897
Residue:
503
Sequence:
MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM
  
Inhibitor
Name:
BDBM481202
Synonyms:
4-(4-((5S,8R)-2-(5-Fluoropyridin-2-yl)-5,6,7,8-tetrahydro-5,8-methanoimidazo[1,2-a]pyridin-3-yl)pyridin-2-yl)benzamide 41-1 | US10906905, Example 41-1
Type:
Small organic molecule
Emp. Form.:
C25H20FN5O
Mol. Mass.:
425.4576
SMILES:
NC(=O)c1ccc(cc1)-c1cc(ccn1)-c1c(nc2[C@@H]3CC[C@@H](C3)n12)-c1ccc(F)cn1 |r|
Structure:
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