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Target
Tyrosine-protein kinase JAK1 [866-1154]
Ligand
BDBM488673
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
IC50
24.5±n/a nM
Citation
 Nilsson, KM; Astrand, AB; Berggren, AI; Johansson, JR; Lepisto, MJ; Kawatkar, SP; Su, Q; Kettle, JG JAK1 selective inhibitors US Patent  US10961228 Publication Date 3/30/2021 
Target
Name:
Tyrosine-protein kinase JAK1 [866-1154]
Synonyms:
JAK1 | JAK1 (aa 866-1154) | JAK1A | JAK1B | JAK1_HUMAN | Tyrosine-protein kinase JAK1 | Tyrosine-protein kinase JAK1 (aa 866-1154)
Type:
Protein
Mol. Mass.:
33185.74
Organism:
Homo sapiens (Human)
Description:
P23458[866-1154]
Residue:
289
Sequence:
DPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK
  
Inhibitor
Name:
BDBM488673
Synonyms:
(R)-N-(3-(5-fluoro-2- ((2-fluoro-3- methylsulfonyl)phenyl) amino)pyrimidin-4- yl)-1H-indol-7-yl)-2- ((3S,5S)-3,4,5- trimethylpiperazin-1- yl)propanamide | US10961228, Example 8
Type:
Small organic molecule
Emp. Form.:
C29H33F2N7O3S
Mol. Mass.:
597.679
SMILES:
C[C@@H](N1C[C@H](C)N(C)[C@@H](C)C1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(C)(=O)=O)ncc1F |r|
Structure:
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