Reaction Details
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Target
Tyrosine-protein kinase JAK1 [866-1154]
Ligand
BDBM488735
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
IC50
<3.00±n/a nM
Citation
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More Info.:
Target
Name:
Tyrosine-protein kinase JAK1 [866-1154]
Synonyms:
JAK1 | JAK1 (aa 866-1154) | JAK1A | JAK1B | JAK1_HUMAN | Tyrosine-protein kinase JAK1 | Tyrosine-protein kinase JAK1 (aa 866-1154)
Type:
Protein
Mol. Mass.:
33185.74
Organism:
Homo sapiens (Human)
Description:
P23458[866-1154]
Residue:
289
Sequence:
DPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK
Inhibitor
Name:
BDBM488735
Synonyms:
(S)-2-((3R,5R)-3,5- dimethylpiperazin-1- yl)-N-(3-(2-((2-fluoro-3- (methylsulfonyl)phenyl) amino)-5- methylpyrimidin-4-yl)- 1H-indol-7- yl)butanamide | US10961228, Example 27
Type:
Small organic molecule
Emp. Form.:
C30H36FN7O3S
Mol. Mass.:
593.715
SMILES:
CC[C@H](N1C[C@@H](C)N[C@H](C)C1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(C)(=O)=O)ncc1C |r|