Reaction Details Report a problem with these data
Target
Adenosine receptor A2a
Ligand
BDBM493797
Substrate
n/a
Meas. Tech.
Binding Assay
Ki
17.0±n/a nM
Citation
 Congreve, MS; Andrews, SP; Mason, JS; Richardson, CM; Brown, GA 1,2,4-triazine-4-amine derivatives US Patent  US10988455 Publication Date 4/27/2021 
Target
Name:
Adenosine receptor A2a
Synonyms:
A2A adenosine receptor (hA2A) | AA2AR_HUMAN | ADENOSINE A2 | ADENOSINE A2a | ADORA2 | ADORA2A | Adenosine A2A receptor (A2AAR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44716.46
Organism:
Homo sapiens (Human)
Description:
P29274
Residue:
412
Sequence:
MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS
  
Inhibitor
Name:
BDBM493797
Synonyms:
US10988455, Example 5(ix)
Type:
Small organic molecule
Emp. Form.:
C16H15N5O
Mol. Mass.:
293.3232
SMILES:
Cc1cn(cc(C)c1=O)-c1nnc(N)nc1-c1ccccc1
Structure:
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