Target
Mitogen-activated protein kinase kinase kinase kinase 1
Ligand
BDBM504002
Substrate
n/a
Meas. Tech.
Binding Assay
Ki
0.118±n/a nM
Citation
 Chan, BDaniels, BDrobnick, JGazzard, LHeffron, THuestis, MLiang, JMalhotra, SMendonca, RRajapaksa, NSiu, MStivala, CTellis, JWang, WWei, BZhou, ACartwright, MWGancia, EJones, GLainchbury, MMadin, ASeward, EFavor, DFong, KCGood, AHu, YHu, BLu, A Naphthyridines as inhibitors of HPK1 US Patent  US11034692 Publication Date 6/15/2021 
Target
Name:
Mitogen-activated protein kinase kinase kinase kinase 1
Synonyms:
HPK1 | M4K1_HUMAN | MAP4K1
Type:
PROTEIN
Mol. Mass.:
91316.07
Organism:
Homo sapiens (Human)
Description:
ChEMBL_586597
Residue:
833
Sequence:
MDVVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSIGDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQPPRDLRSSSPRKQLSESSDDDYDDVDIPTPAEDTPPPLPPKPKFRSPSDEGPGSMGDDGQLSPGVLVRCASGPPPNSPRPGPPPSTSSPHLTAHSEPSLWNPPSRELDKPPLLPPKKEKMKRKGCALLVKLFNGCPLRIHSTAAWTHPSTKDQHLLLGAEEGIFILNRNDQEATLEMLFPSRTTWVYSINNVLMSLSGKTPHLYSHSILGLLERKETRAGNPIAHISPHRLLARKNMVSTKIQDTKGCRACCVAEGASSGGPFLCGALETSVVLLQWYQPMNKFLLVRQVLFPLPTPLSVFALLTGPGSELPAVCIGVSPGRPGKSVLFHTVRFGALSCWLGEMSTEHRGPVQVTQVEEDMVMVLMDGSVKLVTPEGSPVRGLRTPEIPMTEAVEAVAMVGGQLQAFWKHGVQVWALGSDQLLQELRDPTLTFRLLGSPRLECSGTISPHCNLLLPGSSNSPASASRVAGITGL
  
Inhibitor
Name:
BDBM504002
Synonyms:
2-(4-[[8-amino-6-(4-methylpyridin-3-yl)- 2,7-naphthyridin-3-yl]amino]-1H-pyrazol- 1-yl)-2-methylpropan-1-ol | US11034692, Compound 266
Type:
Small organic molecule
Emp. Form.:
C21H23N7O
Mol. Mass.:
389.4536
SMILES:
Cc1ccncc1-c1cc2cc(Nc3cnn(c3)C(C)(C)CO)ncc2c(N)n1
Structure:
Search PDB for entries with ligand similarity: