Reaction Details Report a problem with these data
Target
Homeobox protein PKNOX1
Ligand
BDBM142093
Substrate
n/a
Meas. Tech.
In Vitro Inhibition Assay
IC50
30000±n/a nM
Citation
 Bachovchin, WW; Lai, H; Wu, W Combination therapies using immuno-dash inhibitors and PGE2 antagonists US Patent  US11096924 Publication Date 8/24/2021 
Target
Name:
Homeobox protein PKNOX1
Synonyms:
Homeobox protein PREP-1 | PBX/knotted homeobox 1 | PKNOX1 | PKNX1_HUMAN | PREP1
Type:
Protein
Mol. Mass.:
47590.49
Organism:
Human
Description:
P55347
Residue:
436
Sequence:
MMATQTLSIDSYQDGQQMQVVTELKTEQDPNCSEPDAEGVSPPPVESQTPMDVDKQAIYRHPLFPLLALLFEKCEQSTQGSEGTTSASFDVDIENFVRKQEKEGKPFFCEDPETDNLMVKAIQVLRIHLLELEKVNELCKDFCSRYIACLKTKMNSETLLSGEPGSPYSPVQSQQIQSAITGTISPQGIVVPASALQQGNVAMATVAGGTVYQPVTVVTPQGQVVTQTLSPGTIRIQNSQLQLQLNQDLSILHQDDGSSKNKRGVLPKHATNVMRSWLFQHIGHPYPTEDEKKQIAAQTNLTLLQVNNWFINARRRILQPMLDSSCSETPKTKKKTAQNRPVQRFWPDSIASGVAQPPPSELTMSEGAVVTITTPVNMNVDSLQSLSSDGATLAVQQVMMAGQSEDESVDSTEEDAGALAPAHISGLVLENSDSLQ
  
Inhibitor
Name:
BDBM142093
Synonyms:
US11096924, DASH-inhibitors 1797 | US11559537, Compound 1797 | US8933056, Chg-boroPro | US8933056, Chg-boroPro Thioxamide
Type:
Small organic molecule
Emp. Form.:
C12H23BN2O3
Mol. Mass.:
254.134
SMILES:
N[C@@H](C1CCCCC1)C(=O)N1CCC[C@H]1B(O)O |r|
Structure:
Search PDB for entries with ligand similarity: