Reaction Details Report a problem with these data
Target
Homeobox protein PKNOX1
Ligand
BDBM142092
Substrate
n/a
Meas. Tech.
In Vitro Inhibition Assay
IC50
1300000±n/a nM
Citation
 Bachovchin, WW; Lai, H; Wu, W Combination therapies using immuno-dash inhibitors and PGE2 antagonists US Patent  US11096924 Publication Date 8/24/2021 
Target
Name:
Homeobox protein PKNOX1
Synonyms:
Homeobox protein PREP-1 | PBX/knotted homeobox 1 | PKNOX1 | PKNX1_HUMAN | PREP1
Type:
Protein
Mol. Mass.:
47590.49
Organism:
Human
Description:
P55347
Residue:
436
Sequence:
MMATQTLSIDSYQDGQQMQVVTELKTEQDPNCSEPDAEGVSPPPVESQTPMDVDKQAIYRHPLFPLLALLFEKCEQSTQGSEGTTSASFDVDIENFVRKQEKEGKPFFCEDPETDNLMVKAIQVLRIHLLELEKVNELCKDFCSRYIACLKTKMNSETLLSGEPGSPYSPVQSQQIQSAITGTISPQGIVVPASALQQGNVAMATVAGGTVYQPVTVVTPQGQVVTQTLSPGTIRIQNSQLQLQLNQDLSILHQDDGSSKNKRGVLPKHATNVMRSWLFQHIGHPYPTEDEKKQIAAQTNLTLLQVNNWFINARRRILQPMLDSSCSETPKTKKKTAQNRPVQRFWPDSIASGVAQPPPSELTMSEGAVVTITTPVNMNVDSLQSLSSDGATLAVQQVMMAGQSEDESVDSTEEDAGALAPAHISGLVLENSDSLQ
  
Inhibitor
Name:
BDBM142092
Synonyms:
US11096924, DASH-inhibitors 2401 | US11559537, Compound 2401 | US8933056, Val-boroPro Thioxamide
Type:
Small organic molecule
Emp. Form.:
C9H19BN2O2S
Mol. Mass.:
230.135
SMILES:
CC(C)[C@H](N)C(=S)N1CCC[C@H]1B(O)O |r|
Structure:
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