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Target
GTPase KRas [1-169,G12C,C118A]
Ligand
BDBM515895
Substrate
n/a
Meas. Tech.
Coupled Nucleotide Exchange Assay (20 hours)
IC50
10.00±n/a nM
Citation
 Shin, Y; Cee, VJ; Tegley, CM; Lanman, BA; Wurz, RP; Yang, KC; Ma, VV; Erlanson, D; Jeong, JW; Fucini, RV; Iwig, J KRAS G12C inhibitors and methods of using the same US Patent  US11053226 Publication Date 7/6/2021 
Target
Name:
GTPase KRas [1-169,G12C,C118A]
Synonyms:
GTPase KRas | KRAS | KRAS2 | RASK2 | RASK_HUMAN
Type:
PROTEIN
Mol. Mass.:
19407.24
Organism:
Homo sapiens (Human)
Description:
P01116[1-169,G12C,C118A]
Residue:
169
Sequence:
MTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKADLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK
  
Inhibitor
Name:
BDBM515895
Synonyms:
2-(5-Chloro-2- cyclopropyl-3- ((5-methoxy-3,4- dihydro-2,6- naphthyridin- 2(1H)- yl)carbonyl)-7- methyl-1H-indol- 1-yl)-N-(1-(2- propenoyl)-3- azetidinyl) acetamide | US11053226, Example 1-4
Type:
Small organic molecule
Emp. Form.:
C30H32ClN5O4
Mol. Mass.:
562.059
SMILES:
COc1nccc2CN(CCc12)C(=O)c1c(C2CC2)n(CC(=O)NC2CN(C2)C(=O)C=C)c2c(C)cc(Cl)cc12
Structure:
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