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Target
Cyclin-A2 [177-432]/Cyclin-dependent kinase 2
Ligand
BDBM515904
Substrate
n/a
Meas. Tech.
CDK Kinase Assays
IC50
>300±n/a nM
Citation
 Wang, Y; Wang, J; Ding, L Benzimidazole derivatives, preparation methods and uses thereof US Patent  US11053238 Publication Date 7/6/2021 
Target
Name:
Cyclin-A2 [177-432]/Cyclin-dependent kinase 2
Synonyms:
CDK2/Cyclin A2 | Cyclin-Dependent Kinase 2 (CDK2)
Type:
Protein Complex
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Cyclin-dependent kinase 2
Synonyms:
CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
33938.17
Organism:
Human
Description:
P24941
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
  
Component 2
Name:
Cyclin-A2 [177-432]
Synonyms:
CCN1 | CCNA | CCNA2 | CCNA2_HUMAN | Cyclin A2 | Cyclin-A
Type:
Subunit of Enzyme Complex
Mol. Mass.:
29394.24
Organism:
Human
Description:
P20248[177-432]
Residue:
256
Sequence:
DYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL
  
Inhibitor
Name:
BDBM515904
Synonyms:
4-(6-fluoro-1- methyl-1,2,3,4- tetrahydrobenzo[4,5] imidazo[1,2-a] pyridin-8-yl)-N-(5-(4- methylpiperazin-1- yl)pyridin-2-yl) pyrimidin-2-amine | US11053238, Example 1
Type:
Small organic molecule
Emp. Form.:
C26H29FN8
Mol. Mass.:
472.5605
SMILES:
CC1CCCc2nc3c(F)cc(cc3n12)-c1ccnc(Nc2ccc(cn2)N2CCN(C)CC2)n1
Structure:
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