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Target
Cyclin-A2 [177-432]/Cyclin-dependent kinase 2
Ligand
BDBM515905
Substrate
n/a
Meas. Tech.
CDK Kinase Assays
IC50
>300±n/a nM
Citation
 Wang, Y; Wang, J; Ding, L Benzimidazole derivatives, preparation methods and uses thereof US Patent  US11053238 Publication Date 7/6/2021 
Target
Name:
Cyclin-A2 [177-432]/Cyclin-dependent kinase 2
Synonyms:
CDK2/Cyclin A2 | Cyclin-Dependent Kinase 2 (CDK2)
Type:
Protein Complex
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Cyclin-dependent kinase 2
Synonyms:
CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
33938.17
Organism:
Homo sapiens (Human)
Description:
P24941
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
  
Component 2
Name:
Cyclin-A2 [177-432]
Synonyms:
CCN1 | CCNA | CCNA2 | CCNA2_HUMAN | Cyclin A2 | Cyclin-A
Type:
Subunit of Enzyme Complex
Mol. Mass.:
29394.24
Organism:
Homo sapiens (Human)
Description:
P20248[177-432]
Residue:
256
Sequence:
DYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL
  
Inhibitor
Name:
BDBM515905
Synonyms:
N-(5-((4-ethylpiperazin- 1-yl)methyl) pyridin-2-yl)-5- fluoro-4-(6- fluoro-1-methyl- 1,2,3,4-tetrahydrobenzo [4,5]imidazo[l,2- a]pyridin- 8-yl)pyrimidin-2-amine | US11053238, Example 2
Type:
Small organic molecule
Emp. Form.:
C28H32F2N8
Mol. Mass.:
518.6041
SMILES:
CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3cc(F)c4nc5CCCC(C)n5c4c3)nc2)CC1
Structure:
Search PDB for entries with ligand similarity: