Reaction Details
Report a problem with these data
![](/images/Email.png)
Target
Estrogen receptor [298-554,D538G]
Ligand
BDBM521421
Substrate
n/a
Meas. Tech.
Biochemical Antagonist Activity on Wild Type (WT) and Mutants
IC50
4.00±n/a nM
Citation
![](/images/small/blackdot.gif)
More Info.:
Target
Name:
Estrogen receptor [298-554,D538G]
Synonyms:
ESR | ESR1 | ESR1_HUMAN | Estrogen Receptor alpha (aa 298-554, D538G) | NR3A1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
29170.62
Organism:
Homo sapiens (Human)
Description:
P03372[298-554,D538G]
Residue:
256
Sequence:
KRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYGLLLEMLDAHRLHAPTS
Inhibitor
Name:
BDBM521421
Synonyms:
6-(2,4- dichlorophenyl)- 1-fluoro-5-[6- [(3S)-1-(3- fluoropropyl)pyr- rolidin-3-yl]oxy- 3-pyridyl]-8,9- dihydro-7H- benzo[7]annulen- 2-ol | US11149031, Example 245
Type:
Small organic molecule
Emp. Form.:
C29H28Cl2F2N2O2
Mol. Mass.:
545.448
SMILES:
Oc1ccc2c(CCCC(c3ccc(Cl)cc3Cl)=C2c2ccc(O[C@H]3CCN(CCCF)C3)nc2)c1F |r,c:18|